Charlie Chaplin parodied megalomania in The Great Dictator, his classic comedy about Adolf Hitler. Caused by the spirochete Treponema pallidum, neurosyphilis is rare in industrialized countries today. However, it was once a major cause of neuropsychiatric disorders and still is in developing countries. About 50% of neurosyphilis patients develop general mental paresis (GPI), while 25% develop tabes dorsalis and 25% develop meningovavascular neurosyphilis. Cerebral gummies can also occur. The clinical presentation of patients with these syndromes is now described. Cannabis, Δ9-THC and other cannabinoids induce a range of transient and positive psychotic symptoms qualitatively similar to those of schizophrenia. These symptoms include distrust, paranoid and grandiose delusions, conceptual disorganization, fragmented thinking, and perceptual changes. In addition, Δ9-THC results in depersonalization, derealization, distorted sensory perceptions, altered body perception, and feelings of unreality.

Time perception abnormalities are known to occur in schizophrenia, but have received little attention (Andreasen et al., 1999; Carroll et al., 2009; Davalos et al., 2003; Tysk, 1983). Cannabinoids have been shown to alter the perception of time both in the preclinical period (Conrad et al., 1972; Han and Robinson, 2001; McClure and McMillan, 1997; Schulze et al., 1988) and clinical studies (Hicks et al., 1984; Mathew et al., 1998; McDonald et al., 2003; Sewell and D`Souza, April 3, 2011; Stone et al., 2010; Tinklenberg et al., 1972). Cannabinoids have also been found to interfere with performance in the binocular deep inversion task, a potential surrogate marker of psychosis observed in patients with acute paranoid or schizophreniform schizophrenic psychosis (Koethe et al., 2006). This effect was observed in cannabis resin (Emrich et al., 1991), nabilone (a synthetic analogue of Δ9-THC) (Leweke et al., 2000), dronabinol (a synthetic analogue of THC) (Koethe et al., 2006) and chronic cannabis users (Semple et al., 2003). If you seriously think that you are the only person smart enough to solve the financial crisis and you demand that you take responsibility, people will think you are a megalomaniac. Megalomania is very often portrayed in fiction, usually as the suffering of supervillains. It is not always used strictly correctly; For example, it`s common for a villain to be labeled a “megalomaniac” if they show an obsession with acquiring immense power and wealth (rather than an illusion that they already own these things). However, fiction also contains truly megalomaniac supervillains, and the slightest sense of obsession with grandiose or extravagant things or actions is a common trait of supervillains. Illusions of grandeur are a crazy thirst for power and wealth and a passion for big projects. Comic book villains often suffer from megalomania.

Their plans are only thwarted by superheroes. A megalomaniac is a pathological egoist, that is, someone with a mental disorder with symptoms such as megalomania and obsession with power. We also use the word megalomaniac more informally for people who behave as if they are convinced of their absolute power and greatness. Your egocentric garden variety may be self-centered and arrogant, but it is a bit gentle compared to the megalomaniac who wants to control the world. Psychotic symptoms (e.g., delusions, hallucinations) are commonly seen during episodes of mania, mixed episodes or depression, but are more common in mania and occur in more than half of manic episodes. In manic states, patients often experience grandiose and paranoid delusions as well as perceptual abnormalities that lead to visual, auditory and olfactory experiences. These perceptual changes often begin with the patient describing increased awareness of the environment, which then develops into a “chaos of the senses” and eventually leads to open hallucinations. A number of manic patients have described an increased experience of sensory input, whether colors, sounds, or smells. This then merges with cognitive distractibility and accelerated mental processes, and even merges with greatness.